姓名职称：

高玉伟 研究员，博士生导师

 

教育经历：

1995/05-1999/06 解放军农牧大学，兽医系，本科，兽医公共卫生专业

2000/09-2003/06 解放军军需大学，动物医学院，硕士，预防兽医学专业，导师：夏咸柱

2003/09-2006/06 吉林大学，动物医学院，博士，预防兽医学专业，导师：夏咸柱院士

2006/09-2009/06 中国农业科学院国家禽流感参考实验室，博士后，预防兽医学专业，导师：陈化兰

2016/03-2017/03：美国威斯康星大学麦迪逊分校，访问学者 ，导师：Yoshihiro Kawaoka 院士

 

工作经历：

1999/07-2000/09 解放军北京军区呼伦贝尔军分区，助理员

2006/06-2010/09中国人民解放军军事医学科学院军事兽医研究所，职位：助理研究员

2020/09-2012/12 中国人民解放军军事医学科学院军事兽医研究所，职位：副研究员

2015/12-至今 军事科学院军事医学研究院军事兽医研究所，职位：研究员

2017/09-至今 军事科学院军事医学研究院军事兽医研究所，职位：所长

 

研究兴趣，领域：

研究方向：以新发、突发人兽共患病/重大人兽共患传染病跨种传播机制研究以及以流感病毒为主的呼吸道传染病等致病机制研究。

1.首次明析了我国野生动物携带流感病毒等重要病原体的病原生态学特点，为重要疫病综合防控提供科学依据；获得了野生动物特有毒株，为跨种传播的理论探索和疫苗研发提供了稀缺资源

2.率先建立了多种动物模型，解析了动物流感病毒的感染与跨种传播机制，为其预报预警与防控提供了理论支撑

3.率先开展以湖北省为中心，周边省份及重要野生动物栖息地的野生动物为研究目标，进行与人类密切接触的野生动物携带新型冠状病毒/其他病原题本底调查研究。

4.首次开展穿山甲，刺猬，食蟹猴，金黄地鼠等对新型冠状病毒的感染模型及感染机制的研究。

5.利用世界前沿技术开展新型基因工程疫苗研究，为重要疫病防控提供物质储备和技术支撑。

 

开设课程：

校外导师

 

主持或参加科研项目及人才计划项目情况：

1.基于动物预警的生物威胁防控关键技术研究(AWS17J016)， 十三五重大科技专项项目主持人，2017/01-2020/12，2500万，项目主持。

2.候鸟禽流感病毒多样性、时空动态及分子流行病学研究(3197030205)，国家自然科学基金， 2019/01-2021/12，25万，负责人。

3.与人类密切接触野生动物病原本底及公共卫生安全威胁风险研究(2020YFC0846100) ，国家主体科技计划，2020/01-2020/12，项目主持人，200 万，项目主持。

4.重要候鸟迁徙路线野鸟禽流感主动监测与预警(20200112)，野生动物疫源疫病监测项目主持人， 2020/01-2020/12，25 万，项目主持。

5.（军队课题），2020/02-2020/12，400万，项目主持。

 

代表性论文：

1. Gao, Y., Y. Zhang, K. Shinya, G. Deng, Y. Jiang, Z. Li, Y. Guan, G. Tian, Y. Li, J. Shi, L. Liu, X. Zeng, Z. Bu, X. Xia, Y. Kawaoka, and H. Chen. 2009. Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host. PLoS Pathog 5: e1000709.（IF:9.33）第一作者

2. Shinya, K., Y. Gao, C. Cilloniz, Y. Suzuki, M. Fujie, G. Deng, Q. Zhu, S. Fan, A. Makino, Y. Muramoto, S. Fukuyama, D. Tamura, T. Noda, A.J. Eisfeld, M.G. Katze, H. Chen, and Y. Kawaoka. 2012. Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque. J Virol 86: 6055-6066. （IF:5.4）并列第一作者

3. Yu, Z., X. Gao, T. Wang, Y. Li, Y. Li, Y. Xu, D. Chu, H. Sun, C. Wu, S. Li, H. Wang, Y. Li, Z. Xia, W. Lin, J. Qian, H. Chen, X. Xia, and Y. Gao. 2015. Fatal H5N6 Avian Influenza Virus Infection in a Domestic Cat and Wild Birds in China. Sci Rep 5: 10704. （IF:5.078）通讯作者

4. Sang, X., A. Wang, J. Ding, H. Kong, X. Gao, L. Li, T. Chai, Y. Li, K. Zhang, C. Wang, Z. Wan, G. Huang, T. Wang, N. Feng, X. Zheng, H. Wang, Y. Zhao, S. Yang, J. Qian, G. Hu, Y. Gao, and X. Xia. 2015. Adaptation of H9N2 AIV in guinea pigs enables efficient transmission by direct contact and inefficient transmission by respiratory droplets. Sci Rep 5: 15928. （IF:5.078）通讯作者

5. Feng, N., Y. Yu, T. Wang, P. Wilker, J. Wang, Y. Li, Z. Sun, Y. Gao, and X. Xia. 2016. Fatal canine distemper virus infection of giant pandas in China. Sci Rep 6: 27518. （IF:5.078）通讯作者

6.Zhang, K., W. w. X. , Z. Zhang, J. liu, J. Li, L. Sun, W. Sun, P. Jiao, X. Sang, Z. Ren, Z. Yu, Y. Li, N. Feng, T. Wang, H. Wang, S. Yang, Y. Zhao, X. Zhang, P. R. Wilker, W. Liu, M. Liao, H. C. , Y. Gao, and X. Xia. 2017. The innate immunity of guinea pigs against highly pathogenic avian influenza virus infection. oncotarget:16. （IF:5.008）通讯作者

7.Jin, H., D. Wang, J. Sun, Y. Cui, G. Chen, X. Zhang, J. Zhang, X. Li, H. Chai,Y. Gao, Y. Li, and Y. Hua. 2016. Pathogenesis and Phylogenetic Analyses of Two Avian Influenza H7N1 Viruses Isolated from Wild Birds. Frontiers in microbiology 7:1066. （IF:4.165）通讯作者

8. Qin, J., H. Huang, Y. Ruan, X. Hou, S. Yang, C. Wang, G. Huang, T. Wang, N. Feng, Y. Gao, and X. Xia. 2012. A novel recombinant Peste des petits ruminants-canine adenovirus vaccine elicits long-lasting neutralizing antibody response against PPR in goats. PLoS One 7: e37170. （IF: 4.1）通讯作者

9. Yu, Z., T. Wang, H. Sun, Z. Xia, K. Zhang, D. Chu, Y. Xu, Y. Xin, W. Xu, K. Cheng, X. Zheng, G. Huang, Y. Zhao, S. Yang, Y. Gao, and X. Xia. 2013. Contagious caprine pleuropneumonia in endangered Tibetan antelope, China, 2012. Emerg Infect Dis 19: 2051-2053. （IF:3.287）通讯作者

10. Cheng, K., Z. Yu, H. Chai, W. Sun, Y. Xin, Q. Zhang, J. Huang, K. Zhang, X. Li, S. Yang, T. Wang, X. Zheng, H. Wang, C. Qin, J. Qian, H. Chen, Y. Hua, Y. Gao, and X. Xia. 2014. PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice. Virology 468-470: 207-213. （IF:3.28）通讯作者

11. Yu, Z., W. Sun, X. Li, Q. Chen, H. Chai, X. Gao, J. Guo, K. Zhang, T. Wang, N. Feng, X. Zheng, H. Wang, Y. Zhao, C. Qin, G. Huang, S. Yang, Y. Hua, X. Zhang, Y. Gao, and X. Xia. 2015. Adaptive amino acid substitutions enhance the virulence of a reassortant H7N1 avian influenza virus isolated from wild waterfowl in mice. Virology 476: 233-239. （IF:3.287）通讯作者

12. Ji, X., Z. Ren, N. Xu, L. Meng, Z. Yu, N. Feng, X. Sang, S. Li, Y. Li, T. Wang, Y. Zhao, H. Wang, X. Zheng, H. Jin, N. Li, S. Yang, J. Cao, W. Liu, Y. Gao, and X. Xia. 2016. Intranasal Immunization with Influenza Virus-Like Particles Containing Membrane-Anchored Cholera Toxin B or Ricin Toxin B Enhances Adaptive Immune Responses and Protection against an Antigenically Distinct Virus. Viruses 8: 115. （IF:3.276）通讯作者

13. Cheng, K., Z. Yu, Y. Gao, X. Xia, H. He, Y. Hua, and H. Chai. 2014. Experimental infection of dogs with H6N1 avian influenza A virus. Arch Virol 159: 2275-2282. （IF:2.8）通讯作者

14. Fan, S., L. Zhou, D. Wu, X. Gao, E. Pei, T. Wang,Y. Gao, and X. Xia. 2014. A novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China. Influenza Other Respir Viruses 8: 646-653. （IF:2.38）通讯作者

15. Sun, H., Y. Li, W. Jiao, C. Liu, X. Liu, H. Wang, F. Hua, J. Dong, S. Fan, Z. Yu, Y. Gao, and X. Xia. 2014. Isolation and identification of feline herpesvirus type 1 from a South China tiger in China. Viruses 6: 1004-1014. （IF:3.276）通讯作者

16. Tian, Y., Z. Yu, K. Cheng, Y. Liu, J. Huang, Y. Xin, Y. Li, S. Fan, T. Wang, G. Huang, N. Feng, Z. Yang, S. Yang, Y. Gao, and X. Xia. 2013. Molecular characterization and phylogenetic analysis of new variants of the porcine epidemic diarrhea virus in Gansu, China in 2012. Viruses 5: 1991-2004. （IF:3.276）通讯作者

17. Zhang, K., Z. Zhang, Z. Yu, L. Li, K. Cheng, T. Wang, G. Huang, S. Yang, Y. Zhao, N. Feng, J. Fu, C. Qin,Y. Gao, and X. Xia. 2013. Domestic cats and dogs are susceptible to H9N2 avian influenza virus. Virus Res 175: 52-57. （IF:2.745）通讯作者

18. Zhang, K., W. Xu, Z. Zhang, T. Wang, X. Sang, K. Cheng, Z. Yu, X. Zheng, H. Wang, Y. Zhao, G. Huang, S. Yang, C. Qin, Y. Gao, and X. Xia. 2013. Experimental infection of non-human primates with avian influenza virus (H9N2). Arch Virol 158: 2127-2134. （IF:2.282）通讯作者

19. Sang, X., A. Wang, T. Chai, X. He, J. Ding, X. Gao, Y. Li, K. Zhang, Z. Ren, L. Li, Z. Yu, T. Wang, N. Feng, X. Zheng, H. Wang, Y. Zhao, S. Yang, Y. Gao, and X. Xia. 2015. Rapid emergence of a PB2-E627K substitution confers a virulent phenotype to an H9N2 avian influenza virus during adoption in mice. Arch Virol 160: 1267-1277. （IF:2.282）通讯作者

20. Ren, Z., X. Ji, L. Meng, Y. Wei, T. Wang, N. Feng, X. Zheng, H. Wang, N. Li, X. Gao, H. Jin, Y. Zhao, S. Yang, C. Qin, Y. Gao, and X. Xia. 2015. H5N1 influenza virus-like particle vaccine protects mice from heterologous virus challenge better than whole inactivated virus. Virus Res 200: 9-18. （IF:2.287）通讯作者

21. Yu, Z., K. Cheng, Y. Xin, W. Sun, X. Li, J. Huang, K. Zhang, S. Yang, T. Wang, X. Zheng, H. Wang, Y. Hua, H. Chai, C. Qin, J. Qian, Y. Gao, and X. Xia. 2014. Multiple amino acid substitutions involved in the adaptation of H6N1 avian influenza virus in mice. Vet Microbiol 174: 316-321. （IF:2.276）通讯作者

22. Yu, Z., K. Cheng, W. Sun, Y. Xin, J. Cai, R. Ma, Q. Zhao, L. Li, J. Huang, X. Sang, X. Li, K. Zhang, T. Wang, C. Qin, J. Qian, Y. Gao, and X. Xia. 2014. Lowly pathogenic avian influenza (H9N2) infection in Plateau pika (Ochotona curzoniae), Qinghai Lake, China. Vet Microbiol 173: 132-135. （IF:2.276）通讯作者

23. Feng, N., Y. Liu, J. Wang, W. Xu, T. Li, T. Wang, L. Wang, Y. Yu, H. Wang, Y. Zhao, S. Yang, Y. Gao, G. Hu, and X. Xia. 2016. Canine distemper virus isolated from a monkey efficiently replicates on Vero cells expressing non-human primate SLAM receptors but not human SLAM receptor. BMC Vet Res 12: 160. （IF:1.64）通讯作者

24. Fan, S., T. Wang, X. Gao, Y. Ying, X. Li, Y. Li, Y. Li, J. Ma, H. Sun, D. Chu, Y. Xu, S. Yang, Q. Li, Y. Gao, and X. Xia. 2015. Phylogenetic analysis of Newcastle disease viruses isolated from wild birds in the Poyang Lake region of China. J Vet Med Sci 77: 1143-1149. （IF:0.88）通讯作者

25.Guo, Z. D., Z. Y. Wang, S. F. Zhang, X. Li, L. Li, C. Li, Y. Cui, R. B. Fu, Y. Z. Dong, X. Y. Chi, M. Y. Zhang, K. Liu, C. Cao, B. Liu, K. Zhang, Y. W. Gao, B. Lu and W. Chen, 2020: Aerosol and Surface Distribution of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospital Wards, Wuhan, China, 2020. Emerg Infect Dis, 26, 1583-1591. 通讯作者

26.Hatta, M., G. Zhong, Y. Gao, N. Nakajima, S. Fan, S. Chiba, K. M. Deering, M. Ito, M. Imai, M. Kiso, S. Nakatsu, T. J. Lopes, A. J. Thompson, R. McBride, D. L. Suarez, C. A. Macken, S. Sugita, G. Neumann, H. Hasegawa, J. C. Paulson, K. L. Toohey-Kurth and Y. Kawaoka, 2018: Characterization of a Feline Influenza A(H7N2) Virus. Emerg Infect Dis, 24, 75-86.共同第一作者

27.Liu, J., Z. Ren, H. Wang, Y. Zhao, P. R. Wilker, Z. Yu, W. Sun, T. Wang, N. Feng, Y. Li, H. Wang, X. Ji, N. Li, S. Yang, H. He, C. Qin, Y. Gao and X. Xia, 2018: Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses. Int Immunopharmacol, 63, 119-128. 通讯作者

28.Ren, Z., Y. Zhao, J. Liu, X. Ji, L. Meng, T. Wang, W. Sun, K. Zhang, X. Sang, Z. Yu, Y. Li, N. Feng, H. Wang, S. Yang, Z. Yang, Y. Ma, Y. Gao and X. Xia, 2018: Intramuscular and intranasal immunization with an H7N9 influenza virus-like particle vaccine protects mice against lethal influenza virus challenge. Int Immunopharmacol, 58, 109-116. 通讯作者

29.Yu, Z., K. Cheng, W. Sun, X. Zhang, X. Xia and Y. Gao, 2018a: Multiple adaptive amino acid substitutions increase the virulence of a wild waterfowl-origin reassortant H5N8 avian influenza virus in mice. Virus Res, 244, 13-20. 通讯作者

30.Yu, Z., K. Cheng, W. Sun, X. Zhang, X. Xia and Y. Gao, 2018b: PB2 and HA mutations increase the virulence of highly pathogenic H5N5 clade 2.3.4.4 avian influenza virus in mice. Arch Virol, 163, 401-410. 通讯作者

31.Yu, Z., Y. Gao, H. He, Y. Zhao, X. Yuan and K. Cheng, 2019a: Isolation and genetic characterization of H13N8 low pathogenic avian influenza virus from migratory birds in eastern China. Transbound Emerg Dis, 66, 588-591. 通讯作者

32.Yu, Z., H. He, K. Cheng, J. Wu, Y. Gao, W. Chen, X. Yuan and Y. Zhao, 2019b: Genetic characterization of an H13N2 low pathogenic avian influenza virus isolated from gulls in China. Transbound Emerg Dis, 66, 1063-1066. 通讯作者

33.Yu, Z., W. Sun, X. Zhang, K. Cheng, C. Zhao, Y. Gao and X. Xia, 2017a: Multiple amino acid substitutions involved in the virulence enhancement of an H3N2 avian influenza A virus isolated from wild waterfowl in mice. Vet Microbiol, 207, 36-43. 通讯作者

34.Yu, Z., W. Sun, X. Zhang, K. Cheng, C. Zhao, X. Xia and Y. Gao, 2017b: Rapid acquisition adaptive amino acid substitutions involved in the virulence enhancement of an H1N2 avian influenza virus in mice. Vet Microbiol, 207, 97-102.通讯作者

35. Zhang, Y., Q. Zhang, H. Kong, Y. Jiang,Y. Gao, G. Deng, J. Shi, G. Tian, L. Liu, J. Liu, Y. Guan, Z. Bu, and H. Chen. 2013. H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet. Science 340: 1459-1463. （IF:31.4）共同作者

36.Zhang, Y., Q. Zhang, Y. Gao, X. He, H. Kong, Y. Jiang, Y. Guan, X. Xia, Y. Shu, Y. Kawaoka, Z. Bu, and H. Chen. 2012. Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus. J Virol 86: 9666-9674. （IF:5.076）共同作者

37. Yu, Y., X. Wang, T. Jin, H. Wang, W. Si, H. Yang, J. Wu, Y. Yan, G. Liu, X. Sang, X. Wu, Y. Gao, X. Xia, X. Yu, J. Pan, G. F. Gao, and J. Zhou. 2015. Newly Emergent Highly Pathogenic H5N9 Subtype Avian Influenza A Virus. Journal of virology 89:8806-8815.（IF:4.6）共同作者

 

荣誉、奖励及参加学术团体的情况：

1.重要动物病毒病防控关键技术研究与应用，国家科学进步一等奖，第5名

2.A02，军队科学技术进步一等奖，第1名

3.埃博拉出血热疫情防控先进个人，原（国家卫生计生委，人力资源社会保障部，中宣部，外交部，商务部，解放军总政治部，解放军总后勤部），第1名

4.保护森林和野生动物资源先进个人，原（国家林业局），第1名

5.吉林省科学技术奖：我国动物狂犬病监测与诊断技术研究与应用，吉林省科学技术厅，第14名

6.中国微生物学会微生物生物安全专业委员会，委员

7.陕西省林业科学院秦岭大熊猫研究中心学术委员会，委员

8.大熊猫国家公园珍稀动物保护生物学国家林业和草原局重点实验室学术委员会，委员

9.中国野生动物保护协会野生动物疫源疫病专业委员会，专家

10.中国医药教育协会寒区医学专业委员会，常务委员

11.吉林省畜牧兽医学会，副理事长