王敏

简介：

王敏，女，汉族，医学博士，教授，山东诸城人。博士研究生导师。曾从事临床医学工作多年，自1994年开始从事生物医学工程学和生理学的教学科研工作。2012年到美国佐治亚州立大学神经科学研究中心研修。近年来主要从事以帕金森病大鼠模型为基础的相关神经病理生理学研究，侧重神经电生理学。主要技术是用在体多通道记录技术（Plexon）,经植入脑内不同脑区或核团的微电极阵列，记录大鼠清醒安静或特定运动状态下的脑神经元细胞外单细胞放电活动，进一步用计算机分析软件（offline sorting; Neuroexplorer;Metlab）分析处理。相关技术主要有激光共聚焦显微扫描、免疫组织化学、荧光示踪、透射电镜和免疫印迹等。近几年来主持完成国家自然科学基金课题2项、山东省重大创新工程1项、山东省自然基金课题5项和山东省科技发展计划课题5项。发表科研论文60余篇，专著2部。授权发明专利11项。获山东省技术发明奖一等奖1项。山东省科学技术进步二等奖1项。

近五年主持/承担的项目

1. 山东省重大科技创新工程项目项（2018CXGC1502），帕金森病相关脑区环路信号筛选与干预治疗新方法的研究，2018/01—2021/01，主持。

2．山东省重点研发项目（2016GSF201058），基于帕金森病模型的脑细胞外放电分析与控制基础研究，2017/01—2019/01，主持。

3.国家自然科学基金面上项目（ZR2014CM019），帕金森病大鼠内侧苍白球对丘脑束旁核脑电活动调控及信号通路研究，2016/01-2019/12，主持。

4.山东省自然科学基金面上项目（3157110），帕金森病大鼠内侧苍白球及丘脑束旁核电生理特性及相关性研究，2015/01-2017/12，主持。

5．山东省科技发展计划项目（2011GGB01004），脑起搏器相关信号研究，2013/01—2016/12，主持。

6．山东省自然科学基金面上项（ZR2010CM055），局部场电位与运动编码的研究，2012/01-2015/01，主持。

近五年的主要科研成果

期刊论文:

1. Wang, Xuenan^#, Geng, Xiwen^#,Li, Min,Xie, Jinlu,Chen, Dadian,Han, Hongyu,Meng, Xiaoqian, Yao, Xiaomeng, Zhang, Haiyan,Gao, Yunfeng,Chang, Hongli ,Zhang, Xiao,Wang, Yanan,Wang, Min*, Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions, Frontiers in Neuroscience 2019 , (13)1034, 1-15

2. Haiyan Zhang^#, Jing Yang^#, Tianyu Xiang, Shuang Sun, Xiusong Wang, Xuenan Wang, Min Li, Mengnan Guo, Qingmei Jia，Dadian Chen，Min Wang * , State-dependent spike and local field synchronization between the thalamic parafascicular nucleus and dorsal striatum in a rat model of Parkinson's disease, Neuronscience,2019. (404) 27–38

3. Xiwen Geng^#,Xuenan Wang^#, He Feng，Xiao Zhang Jinlu Xie, Guangheng Gao, Hongyu Han, Xiaomeng Yao, Haiyan Zhang, Yunfeng Gao, Yanan Wang, Min Wang*. Spike and local field synchronization between pedunculopontine nucleus and primary motor cortex in a rat model of Parkinson’s disease. Neuronscience, 2019( 404) 470–483

4. Min Wang *, Qu Qingyang ,He Tingting ,Li Min, Song Zhimin, Chen Feiyu Zhang Xiao, Xie Jinlu ,Geng Xiwen ,Yang Maoquan ,Wang Xiusong, Lei Chengdong ,Hou, Yabing，Distinct temporal spike and local field potential activities in the thalamic parafascicular nucleus of parkinsonian rats during rest and limb movement, Neuroscience 330 (2016) 57–71 9

5. Min Wang*, Min Li, Xiwen Geng, Zhimin Song, H Elliott Albers , Maoquan Yang, Xiao Zhang, Jinlu Xie, Qingyang Qu, Tingting He. Altered neuronal activity in the primary motor cortex and globus pallidus after dopamine depletion in rats. Journal of the Neurological Sciences, 2015. 348(1–2): 231-240.

6. Chuanfen Li, Wen Jin, Xiaoling Wang, Tao Li, Min Wang*, Bingzhen Cao. Establishment and identification of a novel HTRA1 mutation mice model . Reviews in Cardiovascular Medicine, 2019, 20(3): 179-186

7. Haiyan Zhang , Jing Yang, Xuenan Wang, Xiaomeng Yao,Hongyu Han, Yunfeng Gao, Tianyu Xiang ,Shuang Sun, Yanan Wang, XiusongWang, Min Wang* Altered local field potential relationship between the Parafascicular thalamic nucleus and dorsal striatum in hemiparkinsonian rats, Neuronscience bulletin 2019, 35(2):315–324

8. Xiao Zhang, Xiwen Geng, Min Li, Jinlu Xie, Guangheng Gao, Xuenan Wang, Hongyu Han, Min Wang*,Correlation between Spike Potential and Field Potential in the Motor Cortex of Rats with Parkinson’s Disease. NeuroQuantology, 2018,16 (1)，172-178

9. Xiao Zhang, Guangheng Gao, Min Wang*, Jimin Yang, Multi-channel Wireless Local Field Potential Acquisition Based on STM32W, Progress in Engineering and Science, 2017;42:6, 2502-06

10.Xiwen Geng , Jinlu Xie , Xuenan Wang , Xiusong Wang , Xiao Zhang ,Yabing Hou Chengdong Lei , Min Li , Qingyang Qu , Tingting He , Hongyu Han, Min Wang^*, Altered neuronal activity in the pedunculopontine nucleus: An electrophysiological study in a rat model of Parkinson’s disease, Behavioural Brain Research 305 (2016) 57–64 )

11.Xiwen Geng , Xuenan Wang , Jinlu Xie , Xiao Zhang , Xiusong Wang ,Yabing Hou , Chengdong Lei , Min Li , Hongyu Han , Xiaomeng Yao , Qun Zhang ,Min Wang^*,Effect of l-DOPA on local field potential relationship between the pedunculopontine nucleus and primary motor cortex in a rat model of Parkinson’s disease, Behavioural Brain Research 315 (2016) 1–9 (SCI, 3.0)

12. Xiusong Wang，Lei Liu，Wendy Adams Shouxin Li，Qian Zhang，Bingjin Li, Min Wang*Ranji Cui，Cocaine exposure alters dopaminergic modulation of prefronto-accumbens transmission, Physiology & Behavior 145 (2015) 112–117

13.Feng He, Xiwen Geng, Min Wang ,hongbin Ai, Effect of electroacupuncture on the activity of corticotrophin-releasing hormone neurons in the hypothalamus and amygdala in rats exposed to restraint water-immersion stress, Acupuncture in Medicine, 2018; 0:1–7.

14 Feng He, Hongbin Ai Min Wang, Xiusong Wang,Xiwen Geng, Altered Neuronal Activity in the Central Nucleus of the Amygdala Induced by Restraint Water-Immersion Stress in Rats Neuronscience bulletin 2018;36:394–400

授权专利

1.王敏，曲庆洋等，一种大鼠行为红外线识别系统及其使用方法和应用， 201510412844.1

2.王敏，谢金鹿等，一种帕金森大鼠模型的制作方法与应用， 201510516069.4

3.王敏,耿希文等，一种多通道阵列微电极的制作模具及其工作方法, 201510452157.2

4.王敏,谢金鹿等，一种能同时刺激和采集信号的电极及其制备方法201510532596.4

5王敏,姚晓萌等，一种脑内核团给药金属导管201820161871.5

6.王敏，王雪楠等，一种在体电生理学引导下的单细胞标记装置（201910074189.7）

7.王敏,李敏等，一种阵列式玻璃微管灌注装置及其制备方法（20180000379.8）

邮箱：wangmin@sdnu.edu.cn